As technology has become more integral in biological sciences, the field of cyberbiosecurity has become relevant. Focusing specifically on the work being done in genomic analysis, this piece works to identify significant vulnerabilities and develop a risk management framework. By doing so, researchers can prevent possible harms that could be caused by bad-faith actors within the field. Particularly in genomic sequencing, risks of biological “bugs” – analogous to bugs in computer science – raise understandable concern. As the field stands now, there are concerning weaknesses in the confidentiality, integrity, and availability of sensitive biological data. A multi-faceted approach was outlined in order to guide ongoing work and future research.