A trend of growth in the Global Information Environment (GIE) has brought with it an unprecedented level of cyber attacks. In order to harness the advantages of cyberspace, there is a critical need for a system capable of differentiating between normal and anomalous activities. Consequently, the proposition arises for the deployment of a cyber immune system, modeled after human biology, designed to preemptively avoid both repeating attacks and emerging threats. In such a system, cyber attacks can be thought of as ‘viruses’, and defense mechanisms mirroring those of the body can be developed. Analogous to the body’s protective skin, an external firewall can serve as the initial line of defense, while an adaptive immune system identifies and neutralizes hostile antigens, such as ransomware and Trojans, through targeted eradication or quarantine measures. Embracing the principles of bio-inspired cybersecurity offers a promising avenue for developing effective countermeasures against cyber threats.